is supported by Scientific Research on Innovative Areas (22123009) from MEXT, Japan. The source code for both the processing pipeline and figure generation can be accessed publicly at: and, respectively.įunding: This work was supported by the program for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) from the Japan Agency for Medical Research and Development AMED: grant number JP15dm0207001 to H.S., M.F.R., J.H., C.P., H.O., S.I., T.Y., A.W, grant number JP19dm0207088 to K.N., and grant number JP18dm0207030 to K.D.
The image data is also openly available as NIfTI files on the RIKEN CBS data portal at. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: Links for accessing the BMCR-Explorer ( ), as well as for downloading the NIfTI files, data and tools, are provided on the Brain/MINDS data portal at. Received: JanuAccepted: Published: June 29, 2023Ĭopyright: © 2023 Skibbe et al.
PLoS Biol 21(6):Īcademic Editor: Henry Kennedy, Inserm U1208, FRANCE (2023) The Brain/MINDS Marmoset Connectivity Resource: An open-access platform for cellular-level tracing and tractography in the primate brain. This paper introduces the BMCR image preprocessing pipeline and resources, which include new tools for exploring and reviewing the data.Ĭitation: Skibbe H, Rachmadi MF, Nakae K, Gutierrez CE, Hata J, Tsukada H, et al. Moreover, the inclusion of tractography data from diffusion MRI allows systematic analyses of this noninvasive modality against gold-standard cellular connectivity data, enabling detection of false positives and negatives, which provide a basis for future development of tractography. The present release of the BMCR focuses on the prefrontal cortex (PFC), a uniquely developed region of the primate brain that is linked to advanced cognition, including the results of 52 anterograde and 164 retrograde tracer injections in the cortex of the marmoset. This feature, allied to an unprecedented high resolution, enables analyses of features such as reciprocity, directionality, and spatial segregation of connections. Unlike other existing image explorers, the BMCR allows visualization of data from different individuals and modalities in a common reference space. Here, we report on the implementation and features of the Brain/MINDS Marmoset Connectivity Resource (BMCR), a new open-access platform that provides access to high-resolution anterograde neuronal tracer data in the marmoset brain, integrated to retrograde tracer and tractography data. Thus, it is important that we gain insight on its structure to provide a solid basis for models that will clarify function.
The primate brain has unique anatomical characteristics, which translate into advanced cognitive, sensory, and motor abilities.
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